Hepatoprotective and antioxidant effects of Cichorium endivia L. leaves extract against acetaminophen toxicity on rats

The current study was carried out to elucidate the effect of hydroalcoholic extract of Cichorium endivia L.leaves (HCE) against acetaminophen-induced oxidative stress and hepatotoxicity in male rats. Oral administration of acetaminophen produced liver damage in rats as manifested by the significant increase in liver MDA and serum total lipids, total cholesterol, creatinine, total bilirubin and enzyme activities (AST, ALT and ALP). While a significant decrease in the levels of liver GSH, GST, SOD, CAT, serum total protein and albumin was recorded. Pre-treatment of rats with C.endivia leaves extract or silymarin for 21 days succeeded to modulate these observed abnormalities resulting from acetaminophen as indicated by the pronounced improvement of the investigated biochemical and antioxidant parameters. These results substantiate the potential hepatoprotective and antioxidant activity of C.endivia leaves extract. In addition, the hepatoprotective activity of HCE was found to be compatible with silymarin as a known hepatoprotective drug.